Piomiositis de los obturadores tratada con drenaje percutáneo guiado por ecografía en un niño. Presentación de un caso / Obturator pyomyositis in a pediatric patient resolved by ultrasound-guided percutaneous drainage. Case report

El objetivo de esta presentación es dar a conocer el manejo de la miositis piógena del músculo obturador interno en un paciente pediátrico que fue tratado mediante un drenaje percutáneo guiado por ecografía. Se trata de un niño de 5 años de edad, con manifestaciones clínicas y valores de laboratorio de infección muscular profunda en el obturador interno. Se identificó específicamente con resonancia magnética, es un área de difícil acceso quirúrgico, por lo cual se realizó un tratamiento percutáneo guiado por ecografía que permitió drenar el contenido purulento de la zona afectada. La resonancia magnética hizo posible lograr un diagnóstico más acertado en los casos de infección piógena temprana y, a su vez, decidir la vía de abordaje más adecuada. En ocasiones, se puede optar por la guía ecográfica con la cual se evita el abordaje quirúrgico formal y así disminuyen las complicaciones de la herida y la mayor morbimortalidad. La adición de procedimientos percutáneos guiados por imágenes es una herramienta muy útil para tratar enfermedades infecciosas y una gran ayuda para el ortopedista. Nivel de Evidencia: V

The objective of this case report is to present the management of a case of pyogenic myositis of the obturator muscle in a pediatric patient using ultrasound-guided percutaneous drainage. The patient is a 5-year-old pediatric patient with clinical and laboratory manifestations of deep muscular infection at the obturator level, an area of difficult surgical access, for which the least invasive treatment possible was used to drain purulent content from the affected area. The use of magnetic resonance imaging studies allows for a more accurate diagnosis in cases of early pyogenic infection, as well as determining the most effective approach to treatment. In some cases, ultrasound guidance can be used to avoid a formal surgical approach, reducing wound complications and morbidity and mortality. The addition of image-guided percutaneous procedures is a very useful tool for the treatment of infectious diseases and a great help to the orthopedist. Level of Evidence: V

Piomiositis, artritis séptica y osteomielitis aguda porStaphylococcus aureus meticilino resistente de la comunidad enpaciente pediátrico / Pyomyositis, septic arthritis and acute osteomyelitis due tocommunity methicillin-resistant Staphylococcus aureus in apediatric patient

Las infecciones osteoarticulares y musculoesqueléticas son patologías infecciosas relativamente infrecuentes en la infancia, afectando generalmente a varones y menores de 5 años. Países desarrollados reportan una incidencia anual de osteomielitis de 10 a 80/100.000 niños y de 4 casos/100.000 niños para artritis séptica. En países tropicales, la piomiositis tiene una incidencia de un caso por cada 2.000 habitantes. El Staphylococcus aureus es el principal agente causal. En la infancia la vía más común del legada del germen a la articulación es la hematógena. Hasta en un 30% de niños coexisten osteomielitis aguda y artritis séptica. Se presenta el caso de preescolar masculino de 3años, quien posterior a aplastamiento de miembro inferior izquierdo, presenta aumento de volumen, dolor y limitación para la marcha, asociándose 9 días después fiebre de 39.5°C,acudiendo al Hospital Universitario de Caracas. La anamnesis, evaluación clínica y estudios paraclínicos fueron sugestivos depiomiositis de muslo izquierdo, osteomielitis de fémur izquierdo y artritis séptica de rodilla izquierda. Se indica antibioticoterapiacon cobertura para Staphylococcus aureus (ciprofloxacina y clindamicina). Se realizó artrotomía evacuadora y limpieza quirúrgica de estructuras afectadas. El cultivo reportó Staphylococcus aureus sensible a ciprofloxacina, gentamicina, linezolid, rifampicina, trimetropin/sulfametoxazol; resistentea clindamicina, eritromicina, oxacilina, por lo que se omitióclindamicina y se indicó trimetropin/sulfametoxazol. Cumplió21 días de tratamiento intravenoso, observándose evolución satisfactoria por lo que se decidió egreso, dando continuidad con tratamiento vía oral por cuatro semanas y seguimiento interdisciplinario. El abordaje oportuno y adecuado de estas patologías disminuye el riesgo de desarrollar complicaciones(AU)

Osteoarticular and musculoskeletal infections are relatively rare infectious diseases in childhood, generally affecting men and children under 5 years of age. Developed countries report an annual incidence of osteomyelitis of 10 to 80 / 100,000 children and 4 cases / 100,000 children for septicarthritis. In tropical countries, pyomyositis has an incidence of one case for every 2,000 inhabitants. Staphylococcus aureusis the main causative agent. In childhood the most commonroute of arrival of the germ to the joint is hematogenous.Up to 30% of children coexist acute osteomyelitis and septic arthritis. We present the case of a 3-year-old male preschoolerwho, after crushing his left lower limb, presented an increasein volume, pain, and limited gait, and was associated witha fever of 39.5 ° C 9 days later, going to the University Hospital of Caracas. the anamnesis, clinical evaluation and paraclinical studies were suggestive of pyomyositis of the leftthigh, osteomyelitis of the left femur and septic arthritis of the left knee. Antibiotic therapy with coverage for Staphylococcus aureus (ciprofloxacin and clindamycin) is indicated. Evacuating arthrotomy and surgical cleaning of affected structures were performed. The culture reported Staphylococcus aureus sensitiveto ciprofloxacin, gentamicin, linezolid, rifampin, trimetropin /sulfamethoxazole; resistant to clindamycin, erythromycin,oxacillin, therefore clindamycin was omitted and trimetropin /sulfamethoxazole was indicated. He completed 21 days ofintravenous treatment, observing satisfactory evolution so hisdis charge was decided, continuing with oral treatment for four weeks and interdisciplinary follow-up. The timely and adequate approach to these pathologies reduces the risk of developing complications(AU)

Guía de Práctica Clínica para el Diagnóstico y Manejo de las Infecciones de Piel y Tejidos Blandos en Colombia / Clinical Practice Guidelines for the Diagnosis and Management of Skin and Soft Tissue Infections in Colombia

Las infecciones de piel y tejidos blandos (IPTB) representan la tercera causa de consulta por enfermedad infecciosas a los servicios médicos, después de las infecciones respiratorias y urinarias. Se presenta una guía de práctica clínica (GPC) con 38 recomendaciones basadas en la evidencia, graduadas bajo el sistema SIGN, para el diagnóstico y tratamiento de pacientes adultos con IPTB en el contexto colombiano, posterior a un proceso de adaptación de GPC publicadas y la búsqueda sistemática y síntesis de literatura para la actualización de la evidencia científica. Además, se realizó un consenso de expertos para la evaluación de las potenciales barreras para la implementación de las recomendaciones y la evaluación del grado de recomendación en el contexto local.

Skin and soft tissue infections (SSTI) represent the third leading cause of infectious disease consultation for medical services after respiratory and urinary tract infections. This document generates a clinical practice guideline with 38 recommendations based on evidence, graduated under the SIGN system for the diagnosis and treatment for SSTI infections in adult patients in Colombia, following a process of adaptation of guidelines published, and the systematic search and synthesis of literature for the updating of scientific evidence. In addition, a consensus of experts was made for the evaluation of the potential barriers for the implementation of the recommendations and the evaluation of the degree of recommendation in the local context.

Piomiositis por Streptococcus pyogenes en un paciente con malformación venolinfática. A propósito de un caso en pediatría / Pyomyositis due to Streptococcus pyogenes in a patient with venolymphatic malformation. Report of one pediatric case

Las infecciones por Streptococcus pyogenes son frecuentes en la población pediátrica en forma de faringoamigdalitis o cuadros cutáneos. Con menor frecuencia, se presenta con formas invasivas, tales como piomiositis o fascitis necrotizante. La mortalidad en niños reportada en estas últimas es de un 7,69 %. Se presenta a una paciente de 11 años con malformación venolinfática subescapular que consultó por síndrome febril asociado a dolor y aumento agudo del tamaño de la lesión. Durante la internación, se arribó al diagnóstico de piomiositis por Streptococcus pyogenes

Streptococcus pyogenes infections are common in the pediatric population in the form of tonsillopharyngitis or cutaneous disease. Less frequently, it presents with invasive forms such as pyomyositis or necrotizing fasciitis. Mortality in children is of 7 %. We present an 11-year-old patient with a subscapular venolymphatic malformation who consulted for febrile syndrome associated with pain and an acute increase in the size of the lesion. During the hospitalization, diagnosis of pyomyositis due to Streptococcus pyogenes was reached.

Piomiositis en niños: experiencia en un hospital pediátrico de referencia en Argentina / Pediatric pyomyositis: experience in a Pediatric Reference Center in Argentina

Resumen Introducción: La piomiositis es la infección del músculo esquelético, entidad poco frecuente en pediatría. Objetivo: Describir las características de 21 niños con piomiositis. Métodos: Estudio prospectivo-analítico de niños ingresados con diagnóstico de piomiositis entre mayo de 2016 y abril de 2017 en el Hospital de Niños Ricardo Gutiérrez, Buenos Aires, Argentina. Resultados: Tasa de hospitalización de 21,5/10.000 admisiones (IC 95% 4,65- 71,43). La mediana de edad fue de 5,4 años (rango 1,25-11,6). El 90,4% presentaba algún factor predisponente. La localización más frecuente fue en miembros inferiores. La proteína C reactiva (PCR) estuvo elevada en todos los pacientes, con una media de 124 mg/L (DS 96), siendo significativamente más elevada en los pacientes que tuvieron hemocultivos positivos 206 (DS 101) vs 98 (DS 81), (p = 0,02). Se obtuvo rescate microbiológico en 17 pacientes (80,9%): Staphylococcus aureus resistente a meticilina (SARM) (n: 15) y Streptococcus pyogenes (n: 2). Se presentó con bacteriemia 23,8% de los pacientes. El 81% requirió drenaje quirúrgico. Conclusión: Staphylococcus aureus RM adquirido en la comunidad (SARMAC) es el patógeno predominante. En la selección del tratamiento empírico adecuado debería tenerse en cuenta: el patrón de resistencia local y el valor de PCR.

Background: Pyomyositis is the infection of skeletal muscle, a rare pathology in children. Aim To describe the characteristics of pyomyositis in pediatric patients. Methods: Prospective analytical study of hospitalized children diagnosed with pyomyositis from May 2016 to April 2017 at the Ricardo Gutiérrez Children's Hospital, Buenos Aires, Argentina. Results: Twenty-one patients with pyomyositis were identified. Annual rate: 21.5/10,000 admissions (95% CI 4.65-71.43). The median age was 5.4 years (range 1.25-11.6). The lower limbs were the most affected site. C-reactive protein (CRP) was elevated in all patients, with a mean of 124 mg/L (SD 96), being significantly higher in patients with bacteremia: 206 (DS 101) vs 98 (DS 81), p = 0.02. Bacterial cultures were positive in 17/21 (80.9%): 15 methicillin-resistant Staphylococcus aureus (MRSA), and 2 Streptococcus pyogenes. Blood cultures were positive in 5 (23.8%). Conclusion: MRSA-community acquired is the predominant pathogen in our setting. In the selection of the appropriate empirical treatment, the local resistance pattern and the CRP value should be taken into account.

Tropical pyomyositis: diabetes facilitating the onset of an uncommon disease / Piomiosite tropical: diabetes facilitando o aparecimento de uma doença incomum

INTRODUCTION: Tropical pyomyositis is an infectious disease that affects skeletal muscle and may appear as a diffuse inflammation or a rapidly progressive myonecrotic process. The predisposition of this disease in diabetics is already mentioned in several studies. The pathogenesis is possibly related to changes in neutrophils and the reversal of the immune response pattern that occurs in situations such as parasitic diseases. Staphylococcus aureus is the most common microorganism, accounting for 90% of cases of tropical pyomyositis. The diagnosis is sometimes late because patients usually do not seek care by the first symptoms, and because it is a rare disease and physicians are not very familiar with it. CASE REPORT: A 42-year-old male patient with diabetes mellitus, hypothyroidism, anemia, thrombocytopenia, and hypoalbuminemia developed tropical pyomyositis with multiple muscle abscesses in quadriceps, soleus and anterior tibial, triceps and biceps brachialis and pronator round, requiring prolonged antibiotic therapy and surgical drainage. CONCLUSION: Pyomyositis is a little known disease and if not diagnosed early can be fatal.

INTRODUÇÃO: A piomiosite tropical é uma doença infecciosa que afeta o músculo esquelético, aparecendo como uma inflamação difusa ou um processo mionecrótico rapidamente progressivo. A predisposição desta enfermidade em diabéticos já é referida em vários estudos. A patogênese possivelmente está relacionada a alterações nos neutrófilos e na inversão do padrão de resposta imune que acontece em situações como parasitoses. Staphylococcus aureus é o microorganismo mais comum, representando 90% dos casos de piomiosite tropical. O diagnóstico pode ser tardio porque os pacientes geralmente não buscam cuidados com os primeiros sintomas e, por ser uma doença rara, pode surpreender um médico ainda não familiarizado com esta entidade clínica. RELATO DE CASO: Paciente do sexo masculino com 42 anos de idade com diabetes mellitus, hipotireoidismo, anemia, trombocitopenia e hipoalbuminemia que desenvolveu piomiosite tropical com múltiplos abscessos musculares em quadríceps, sóleo e tibial anterior, tríceps e bíceps braquial e pronador redondo, necessitando de antibioticoterapia prolongada e drenagem cirúrgica. CONCLUSÃO: A piomiosite não é uma doença bem conhecida e pode ser fatal se não for diagnosticada precocemente.

Piriformis Pyomyositis in a Patient with Kikuchi-Fujimoto Disease - A Case Report and Literature Review / Piomiosite do piriforme em um paciente com doença de Kikuchi-Fujimoto-relato de caso e revisão da literatura

Abstract Primary pyomyositis is a deep bacterial infection of the skeletal muscle. If left undiagnosed and untreated, the infection spreads, leading to sepsis, septic shock, and even death. The authors report a 23-year-old female presenting with piriformis pyomyositis during a treatment for Kikuchi-Fujimoto disease. Pyomyositis is a rare but potentially severe infection, which can lead to septic shock. The present case shows the need for a high degree of clinical suspicion for patients with compromised immune systems to begin treatment at an early stage. The literature demonstrates that outcomes of the treatment of piriformis pyomyositis are good.

Resumo A piomiosite primária é uma infecção bacteriana profunda do músculo esquelético. Quando não diagnosticada ou tratada, a infecção pode evoluir para sepse, choque séptico e até morte. Os autores relatam o caso de uma paciente do sexo feminino, 23 anos, apresentando piomiosite do músculo piriforme durante o tratamento da doença de Kikuchi-Fujimoto. A piomiosite é uma infecção rara, mas potencialmente grave, que pode levar ao choque séptico. Esse caso mostra a necessidade em se elevar o grau de suspeição clínica em pacientes com comprometimento do sistema imunológico, para que o tratamento seja iniciado em estágio precoce. A literatura mostra que os resultados do tratamento da piomiosite do piriforme são bons.

Piomiositis del músculo piriforme por Streptococcus pyogenes en un niño / Streptococcus pyogenes pyomyositis of the piriformis muscle in a child

La piomiositis aguda es una infección supurativa del músculo esquelético. El agente etiológico más frecuente es Staphylococcus aureus, y son infrecuentes los casos producidos por Streptococcus pyogenes. Las localizaciones más habituales son cuádriceps, glúteos e iliopsoas; es excepcional la afectación del músculo piriforme. Se presenta el caso de un varón de 8 años, previamente sano, que fue ingresado en nuestro hospital por una piomiositis aguda por Streptococcus pyogenes localizada en el músculo piriforme. El diagnóstico y el inicio precoz del tratamiento antibiótico permitieron el manejo conservador del cuadro y no fue necesaria la cirugía. La evolución fue satisfactoria y no presentó secuelas.

Acute pyomyositis is a suppurative infection of the skeletal muscle. Staphylococcus aureus is the most frequent etiological agent. Cases produced by Streptococcus pyogenes are uncommon. The most usual locations are quadriceps, buttocks and iliopsoas. The involvement of the piriformis muscle is very exceptional. We present the case of a previously healthy 8-year-old male who was admitted to our hospital for acute pyomyositis caused by Streptococcus pyogenes located in the piriformis muscle. Early diagnosis and prompt initiation of antibiotic treatment allowed the conservative management of the condition, and surgery was not necessary. The evolution was satisfactory without sequels.

Piomiositis tropical por escherichia coli en paciente con diabetes mellitus: caso atípico, aspectos clínicos y radiológicos / Tropical piomiositis by escherichia coli in patient with diabetes mellitus: atipic case, clinical and radiological aspects

Antecedentes: Piomiositis es la infección purulenta del músculo esquelético que ocurre por diseminación hematógena, con formación de abscesos, el agente etiológico principal es E. aureus (90%) seguido por Estreptococo beta hemolítico grupo A y bacilos entéricos gram negativos (Ej. E. coli). Es frecuente en pacientes inmunocomprometidos por malignidades hematológicas, relacionadas o no con quimioterapia previa y SIDA. Caso clínico: Masculino de 52 años hospitalizado en el Instituto Hondureño de Seguridad Social, Tegucigalpa, Honduras, síntoma principal dolor opresivo en pelvis de 3 semanas de evolución, con irradiación a cara anterior de muslo derecho, con cambios inlamatorios a este nivel, una semana después dolor y cambios inlamatorios en pierna izquierda. Discusión: En comparación con las personas sanas, los pacientes con condiciones médicas subyacentes tienen mayores tasas de infección por bacterias gram negativas, enfermedad multifocal y mayor mortalidad. El estado de inmunosupresión es un factor predisponente importante en la patogénesis...(AU)

Primary pyomyositis in North India: a clinical, microbiological, and outcome study

BACKGROUND/AIMS: Pyomyositis is an infective condition with primary involvement of the skeletal muscles. There is sparse recent literature on patients with pyomyositis. METHODS: This study was carried out at emergency services of a tertiary care center located in subtropical area of Indian subcontinent. RESULTS: Sixty-two patients of primary pyomyositis formed the study cohort. Mean age of occurrence was 29.9 ± 14.8 years. There were 54 men. Twelve patients had underlying medical diseases. Muscle pain was seen in all 62 patients. Forty-eight patients (77.4%) had the fever. Most common site of involvement was thigh muscles (n = 29, 46.8%). Forty-nine patients (79%) presented in the suppurative stage of illness. Patients with comorbidities were older (age: median 36 years [interquartile range (IQR), 25 to 47] vs. 24 years [IQR, 16 to 35], p = 0.024), had higher culture positivity with gram-negative organisms (8/9 [88.89%] vs. 6/29 [20.69%], p = 0.001). Importantly, higher number of these patients received inappropriate antibiotics initially. Patients with positive pus culture result had higher complication rate (32/38 [84.21%] vs. 10/18 [55.56%], p = 0.044). Six patients (9.7%) had in-hospital mortality. Lower first-day serum albumin, initial inappropriate antibiotic therapy, and advanced form of the disease at presentation were associated with increased in-hospital mortality. CONCLUSIONS: Primary pyomyositis is not an uncommon disease entity. Patients with comorbidities were more likely to receive initial inappropriate antibiotic therapy. Patients with positive pus culture report had the higher rate of complications. Lower first-day serum albumin, initial inappropriate antibiotic therapy and advanced form of the disease at presentation were associated with increased in-hospital mortality.

Pyomyositis and fasciitis by carbapenem resistant microorganism in a patient with severe tophaceus gout / Piomiositis y fascitis asociadas a microorganismo resistente a carbapenémicos, en un paciente con gota tofácea severa

Abstract Pyomyositis, defined as a suppurative muscle infection, is a rare entity that is classified as tropical or non-tropical according to the geographical region. The case of a patient with a history of severe tophaceous gouty arthritis, coming from tropical wet climate in Colombia, who presented with suggestive cellulitis, with a torpid evolution despite standard dual management. An associated abscess was documented, and initially abscessed cellulitis and septic arthritis were suspected, the latter was finally ruled out, once teh muscle origin of the abscess becames evident by means of computed tomography and ultrasonography. Intraoperatively, an abscess with fascia involvement and intramuscular tophaceous disease was observed. Surgical drainage and repeated washes were required. Carbapenem resistant Klebsiella pneumoniae was isolated, requiring last-line Gouty arthritis antibiotic therapy for a prolonged period of time.

Resumen La piomiositis es una infección supurativa del músculo estriado, rara, que se clasifica según la región geográfica de presentación, en tropical y no tropical. Se presenta el caso de un paciente con antecedente de artritis gotosa tofácea severa, proveniente de zona tropical, quien comienza con cuadro sugestivo de celulitis, con evolución tórpida pese a manejo estándar dual; se documenta un absceso de ubicación no clara, sospechando en principio celulitis abscedada y artritis séptica, finalmente descartándose esta última y haciéndose evidente origen muscular del absceso por medio de tomografia computarizada y ultrasonografía. Quirúrgicamente se evidenció absceso con compromiso de fascia, enfermedad tofácea intramuscular; requirió drenaje quirúrgico y lavados, documentándose germen Klebsiella pneumoniae resistente a carbapenémicos, requiriendo antibioticoterapia de última línea por un periodo prolongado.

Clinical Guidelines for the Antibiotic Treatment for Community-Acquired Skin and Soft Tissue Infection

Skin and soft tissue infection (SSTI) is common and important infectious disease. This work represents an update to 2012 Korean guideline for SSTI. The present guideline was developed by the adaptation method. This clinical guideline provides recommendations for the diagnosis and management of SSTI, including impetigo/ecthyma, purulent skin and soft tissue infection, erysipelas and cellulitis, necrotizing fasciitis, pyomyositis, clostridial myonecrosis, and human/animal bite. This guideline targets community-acquired skin and soft tissue infection occurring among adult patients aged 16 years and older. Diabetic foot infection, surgery-related infection, and infections in immunocompromised patients were not included in this guideline.

Piomiositis y espondilodiscitis hematógena en un paciente inmunocompetente / Pyomiositis and hematogenous spondylodiscitis in a immunocompetent patient

Resumen:La piomiositis es una infección bacteriana primaria de músculo esquelético. Anteriormente era una enfermedad solo de pacientes de zonas de clima tropical, por lo que se conocía como piomositis tropical. No obstante, se ha dado un aumento en la aparición de casos en zonas no tropicales en especial en pacientes inmunocomprometidos. Esta condición puede asociarse a bacteremia y por ende a la aparición de focos infecciosos de diseminación hematógena. Se reporta un caso de espondilodiscitis bacteriana secundaria a bacteremia, derivada de una piomiositis de músculo iliopsoas. El paciente consulta por lumbalgia y se le diagnostica absceso en musculo psoas, el cual requirió drenaje percutáneo. No obstante, desarrolla paraplejia fláccida y se sospecha compresión medular. La tomografía espinal demuestra compresión a nivel de segmento C5-C6 secundario a espondilodiscitis, que precisó tratamiento quirúrgico y drenaje de colección.Se aisló también Staphylococcus aureus de este sitio. El caso ilustra la diseminación hematógena de una piomiositis hacia proceso vertebral con déficit neurológico, por compresión medular en un paciente inmunocompetente.

Abstract:Pyomyositis is a primary bacterial infection of skeletal muscle. Formerly, it was a disease present orly in patients in tropical climate zones, thus being known as tropical pyomyositis. Nonetheless there has been an increased incidence in non-tropical climates mainly in immunocompromised patients. This condition may be related to bacteremia and therefore to the appearance of infectious sites through hematogenous dissemination. A case of spondylodiscitis, due to bacteremia from an iliopsoas muscle pyomyositis, is reported. The patient consulted initially for severe low back pain and an abscess in the iliopsoas muscle was diagnosed and percutaneous drainage was required.Few days later, the patient suffered flaccid paralysis of both lower limbs and spinal cord compression was suspected. The spinal tomography scan showed spinal cord compression at C5-C6 level due to spondylodiscitiswhichrequired surgical treatment and drainage. A culture positive for Staphylococcus aureus was also isolated from the area.This case shows hematogenous dissemination of bacterial pyomyositis with spinal compromise and cord compression in an immunocompetent patient.

Piomiositis tuberculosa en un paciente inmunosuprimido / Tuberculous pyomyositis in an immunosuppressed patient

La piomiositis tuberculosa es una manifestación poco frecuente de la tuberculosis extrapulmonar que se presenta más comúnmente en pacientes inmunosuprimidos, con manifestaciones clínicas similares a las de la piomiositis de otras etiologías, pero a una edad más temprana. Los factores de riesgo más usuales son la infección tuberculosa previa y la inmunosupresión farmacológica. El diagnóstico depende de la sospecha clínica en una población expuesta, ya que en muchas ocasiones el aislamiento microbiológico no es posible. La respuesta al tratamiento y el pronóstico son buenos. El caso que se presenta es llamativo dada la rareza de esta manifestación de la tuberculosis y la lenta mejoría con el tratamiento antituberculoso de primera línea en este paciente con infección por HIV y recaída, a pesar de que el aislamiento microbiológico resultó sensible.

Tuberculous pyomyositis is a rare manifestation of extrapulmonary tuberculosis, most common in immunosuppressed patients, with clinical manifestations similar to pyomyositis of other etiologies, although with a lower age of presentation; notable risk factors include prior tuberculosis infection and pharmacological immunosuppression. Diagnosis depends on a high clinical suspicion of the infection in a susceptible population, given that microbiological isolation is often impossible. The response to treatment and prognosis are good. The case presented here is noteworthy given the rarity of this manifestation of tuberculosis and the slow response to first-line TB management in an HIV patient, despite susceptible microbiological isolation.

Piomiosite no lúpus eritematoso sistêmico juvenil / Pyomyositis in childhood-systemic lupus erythematosus

Resumo A piomiosite é uma infecção piogênica da musculatura esquelética, decorrente da disseminação hematogênica e geralmente acompanhada de formação de abscesso localizado. Esta infecção da musculatura é raramente descrita em adultos com lúpus eritematoso sistêmico (LES) e, até onde se sabe, ainda não o foi em pacientes com LES juvenil (LESJ). De nossos 289 pacientes com LESJ, uma apresentou piomiosite. Diagnosticada com LESJ aos 10 anos de idade e após seis anos de tratamento com prednisona, azatioprina e hidroxicloroquina, a paciente foi hospitalizada em razão de um histórico de 30 dias de dor insidiosa na coxa esquerda, sem relato algum de trauma aparente ou febre. O exame físico mostrou músculos sensíveis e com endurecimento lenhoso. Os exames laboratoriais revelaram anemia, aumento de reagentes de fase aguda e enzimas musculares normais. A tomografia computadorizada da coxa esquerda mostrou coleção no terço médio do vasto intermédio, sugerindo estágio purulento de piomiosite. Iniciou-se tratamento com antibiótico de largo espectro, que levou à resolução clínica completa. Em suma, descreveu-se o primeiro caso de piomiosite em pacientes com LESJ encontrado neste serviço. Este relato reforça que a presença de dor muscular localizada em pacientes imunocomprometidos, ainda que sem aumento de enzimas musculares, deve sugerir o diagnóstico de piomiosite. Recomenda-se tratamento imediato com antibióticos.

Abstract Pyomyositis is a pyogenic infection of skeletal muscle that arises from hematogenous spread and usually presents with localized abscess. This muscle infection has been rarely reported in adult-onset systemic lupus erythematous and, to the best of our knowledge, has not been diagnosed in pediatric lupus population. Among our childhood-onset systemic lupus erythematous population, including 289 patients, one presented pyomyositis. This patient was diagnosed with childhood-onset systemic lupus erythematous at the age of 10 years-old. After six years, while being treated with prednisone, azathioprine and hydroxychloroquine, she was hospitalized due to a 30-day history of insidious pain in the left thigh and no apparent trauma or fever were reported. Her physical examination showed muscle tenderness and woody induration. Laboratory tests revealed anemia, increased acute phase reactants and normal muscle enzymes. Computer tomography of the left thigh showed collection on the middle third of the vastus intermedius, suggesting purulent stage of pyomyositis. Treatment with broad-spectrum antibiotic was initiated, leading to a complete clinical resolution. In conclusion, we described the first case of pyomyositis during childhood in pediatric lupus population. This report reinforces that the presence of localized muscle pain in immunocompromised patients, even without elevation of muscle enzymes, should raise the suspicion of pyomyositis. A prompt antibiotic therapy is strongly recommended.

Piomiositis primaria: Revisión de 32 casos diagnosticados por ecografía / Primary pyomyositis. Review of 32 cases diagnosed by ultrasound

La piomiositis primaria es la infección bacteriana por vía hematógena del músculo estriado. Está relacionada con factores de riesgo como HIV/sida y otras enfermedades inmunodepresoras, pudiendo estar asociados a factores locales de estrés muscular. El agente etiológico más frecuente es Staphylococcus aureus. Su retardo diagnóstico puede ocasionar una evolución fatal. En esta serie se evaluaron 32 pacientes con piomiositis primaria diagnosticados por ecografía. El factor de riesgo más frecuente fue el HIV/sida (61%). Los factores locales se detectaron en 21 casos (66%): en primer lugar, la práctica de futbol. La forma monofocal se observó en 19 (59%) los músculos más frecuentemente afectados fueron cuádriceps, gemelos y psoas. Se obtuvieron muestras para estudio bacteriológico en 30 casos, 27 de material del absceso y 22 hemocultivos. En los 30 casos se aisló el agente etiológico. El Staphylococcus aureus representó el 83.3% (25 casos) y Escherichia coli, Nocardia spp., Streptococcus agalactiae, Micobacteria no tuberculosa y Pseudomonas aeruginosa fueron aislados en un caso cada uno. Recibieron tratamiento quirúrgico 17 pacientes, punciones aspirativas, 9; antibióticos solamente, 4. Presentaron buena evolución 28 de los 30 pacientes (93.3%), óbitos, 2 (6.6%); desconocida, 2. Este estudio concluyó que: ante la etiología diversa y cambiante de las piomiositis primarias es importante reconocer el agente involucrado y su sensibilidad antibiótica. La ecografía realiza la evaluación en tiempo real y puede ser utilizada como guía de punción facilitando el diagnóstico inmediato. Esto la diferencia de otras técnicas, transformándola en un método de primera línea para el estudio de esta enfermedad.

Primary pyomyositis is a bacterial infection of striated muscle which is acquired by hematogenous route. It is related to risk factors such as HIV/aids and other immuno suppressing diseases, and can be associated with local muscle stress factors. The most frequent etiology is Staphylococcus aureus. Its diagnostic delay may cause a fatal evolution. In this series 32 patients with primary pyomyositis diagnosed by ultrasound were evaluated. The most frequent risk factor was HIV/aids (61%). Local factors were detected in 21 (66%) cases: first, the practice of football. The monofocal form was observed in 19 (59%), the most commonly affected muscles were quadriceps, calves and psoas. Samples for bacteriological study were obtained in 30 cases, 22 blood culture and 27 abscess materials. In 30 cases the etiologic agent was isolated. Staphylococcus aureus accounted for 83.3% (25 cases) and Escherichia coli, Nocardia spp., Streptococcus agalactiae, nontuberculous mycobacteria, Pseudomonas aeruginosa were isolated in one case each. Seventeen patients received surgical treatment, aspirative punctures, 9; antibiotics alone, 4. Twenty eight (93.3%) patients had a good evolution; deaths, 2 (6.6%); unknown, 2. Main conclusions of this study were: due to the diverse and changing etiology of the primary pyomyositis it is important to recognize the etiological agent involved and their antibiotic susceptibility.The ultrasound performed the study in real time so it can be used to guide the puncture and to facilitate the immediate diagnosis. This makes the difference with other techniques and transforms it into a first-line method for the study of this disease.

Disseminated staphylococcal infection in an immunocompetent adult: A case report

@#<p style="text-align: justify;">Septic pulmonary embolism is an uncommon disorder in which septic thrombi are mobilized from an infectious nidus and transported in the vascular system of the lungs. We report a case of a 52-year-old immunocompetent female who suffered from septic pulmonary embolism associated with polymyositis, deep venous thrombosis and pericardial effusion. Oxacillin-sensitive staphylococcus aureus (MSSA) was isolated from her sputum. Clinical presentation improved after incision of the muscle abscess and vancomycin treatment.</p>

Sonographic Findings of Common Musculoskeletal Diseases in Patients with Diabetes Mellitus

Diabetes mellitus (DM) can accompany many musculoskeletal (MSK) diseases. It is difficult to distinguish the DM-related MSK diseases based on clinical symptoms alone. Sonography is frequently used as a first imaging study for these MSK symptoms and is helpful to differentiate the various DM-related MSK diseases. This pictorial essay focuses on sonographic findings of various MSK diseases that can occur in diabetic patients.

Piomiositis tropical vs. leptospirosis / Tropical pyomyositis vs. leptospirosis

La piomiositis es una infección bacteriana aguda o subaguda del músculo esquelético, caracterizada por la formación intramuscular de uno o más abscesos. Presentamos un paciente con cuadro clínico sospechoso de Leptospirosis y que en el transcurso de su ingreso se le diagnostica la piomiositis tropical. Se describe la evolución del paciente, los estudios realizados y el tratamiento indicado por los especialistas.

Pyomyositis is an acute bacterial infection or subacute skeletal muscle characterized by intramuscular formation of one or more abscess. A patient with leptospirosis-suspected clinical condition is presented here. During the course of his hospitalization, he is diagnosed with tropical pyomyositis. Patient outcomes, studies and treatment prescribed by specialists are described.

Piomiositis: una infección poco explorada / Pyomyositis: ararely explored infection

La piomiositis es una infección bacteriana aguda o subaguda del músculo esquelético que se caracteriza por la acumulación intramuscular de material purulento. Inicialmente se la conocía como piomiositis tropical por su frecuencia en estas zonas climáticas Si bien la piomiositis es poco frecuente en nuestro medio, se la identificó asociada a patologías donde hay disminución de la inmunidad, siendo el Staphylococcus aureus el principal agente etiológico. Se presentan cuatro casos clínicos de pacientes adultos, siendo tres con piomiositis primaria y uno con piomiositis secundaria. En uno de los pacientes se identificó Staphilococcus meticilino resistente de la comunidad. Se realizaron estudios de diagnóstico por imágenes y los pacientes recibieron terapéutica antibiótica prolongada

Pyomyositis is an acute or sub-acute bacterial infection of the skeletal muscle characterized by the accumulation of intramuscular purulent material. It was initially known as tropical pyomyositis because of the frequent occurrence of this affection in tropical areas. Although pyomyositis is quite rare in our area, it was identified in association to other pathologies in which there is a decrease of immunity, being Staphylococcus aureus the main ethiological agent. Four clinical cases in adult patients are presented, three with primary pyomyositis and co-morbidities and one with secondary pyomyositis. In one of the patients, communityresistant Staphylococcus meticilino was identified. Imaging was performed and the patients received long term treatment with antibiotics.